Light cone tensor network and time evolution

The transverse folding algorithm [Phys. Rev. Lett. 102, 240603] is a tensor network method to compute time-dependent local observables in out-of-equilibrium quantum spin chains that can sometimes overcome the limitations of matrix product states. We present a contraction strategy that makes use of the exact light cone structure of the tensor network representing the observables. The strategy can be combined with the hybrid truncation proposed for global quenches in [Phys. Rev. A 91, 032306], which significantly improves the efficiency of the method. We demonstrate the performance of this transverse light cone contraction also for transport coefficients, and discuss how it can be extended to other dynamical quantities

The Effect Of Residents' Place Attachment On Their Attitude Towards Development Of Religious Tourism: The Moderating Effect Of Personal Benefit

Residents’ attitude towards tourism development in religious tourism destinations is especially relevant for tourism planning. Nevertheless, there are few studies that analyse how residents’ attitude towards development of religious tourism is formed. This paper analyses the effect of residents’ place attachment on their attitudes towards development of religious tourism, considering perceived impacts of tourism as mediator and the personal benefit derived from tourism as moderating effect. On the basis of a sample of 410 residents of Montecristi, a religious tourism destination of Ecuador, and using Partial Least Squares Structural Equation Modeling (PLS-SEM), the results show that place attachment directly influences the attitude towards development of religious tourism, but mainly through the perceived impacts of tourism. Moreover, this paper finds that the influence of the perceived impacts on the support for the development of religious tourism is higher in residents with a lower personal benefit than in residents with a higher personal benefit. These findings enable a series of recommendations to be made to the agents concerned regarding the development of religious tourism in sacred destinations

Short communication: Stability and integrity of classical swine fever virus RNA stored at room temperature

Worldwide cooperation between laboratories working with classical swine fever virus (CSFV) requires exchange of virus isolates. For this purpose, shipment of CSFV RNA is a safe alternative to the exchange of infectious material. New techniques using desiccation have been developed to store RNA at room temperature and are reported as effective means of preserving RNA integrity. In this study, we evaluated the stability and integrity of dried CSFV RNA stored at room temperature. First, we determined the stability of CSFV RNA covering CSFV genome regions used typically for the detection of viral RNA in diagnostic samples by reverse transcription-polymerase chain reaction (RT-PCR). To this end, different concentrations of in vitro-transcribed RNAs of the 5’-untranslated region and of the NS5B gene were stored as dried RNA at 4, 20, and 37oC for two months. Aliquots were analyzed every week by CSFV-specific quantitative real-time RT-PCR. Neither the RNA concentration nor the storage temperature did affect CSFV RNA yields at any of the time evaluated until the end of the experiment. Furthermore, it was possible to recover infectious CSFV after transfection of SK-6 cells with dried viral RNA stored at room temperature for one week. The full-length E2 of CSFV was amplified from all the recovered viruses, and nucleotide sequence analysis revealed 100% identity with the corresponding sequence obtained from RNA of the original material. These results show that CSFV RNA stored as dried RNA at room temperature is stable, maintaining its integrity for downstream analyses and applications

Molecular and Clinical Implications of Somatostatin Receptor Profile and Somatostatin Analogues Treatment in Oral Cavity Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) incidence has increased by 50% over the last decade. Unfortunately, surgery and adjuvant radiotherapy and chemotherapy are still the mainstream modality of treatment, underscoring the need for alternative therapies. Somatostatin-analogues (SSA) are efficacious and safe treatments for a variety of tumors, but the presence of somatostatin-receptors (SSTs) and pharmacological effects of SSA on OSCC are poorly known. In this study, we demonstrated that SST2 and SST3 levels were significantly higher in OSCC, compared to adjacent healthy control tissues. SST2 expression was associated with less regional metastasis and a lower recurrence rate. Moreover, SST2 was elevated in OSCC and associated with histopathological good prognosis factors, such as high peritumoral inflammation, smaller depth of invasion, and expansive vs. infiltrative front of tumor invasion. Importantly, treatment with different SSA (octreotide, lanreotide, and pasireotide) significantly reduced cell-proliferation in OSCC primary cell cultures. Altogether, this study demonstrated that SST2 is overexpressed in OSCC vs. healthy tissues and could represent a novel prognostic biomarker, since its expression is associated with tumors that show better prognostic factors and less recurrent rate. Moreover, our data unveil clear antitumoral effects of SSAs on OSCC, opening new avenues to explore their potential as targeting therapy to OSCC

Comunicación del derecho humano a la alimentación adecuada

El presente texto aborda el trabajo realizado durante el periodo de verano del 2020 en el PAP “Comer convoca: acción social para entornos saludables”, específicamente en el escenario del Observatorio del Derecho Humano a la Alimentación Adecuada, el cual busca informar y visibilizar las problemáticas que obstaculizan el cumplimiento y el ejercicio pleno de este derecho en Jalisco desde una visión integral con perspectiva de derechos, seguridad y soberanía alimentaria. Se trabajó fundamentalmente desde el área de comunicación. Entre los principales productos que se generaron destacan las plantillas de publicación para redes sociales con el fin de dar mayor identidad y continuidad a las publicaciones del Observatorio; los diseños de las publicaciones para el periodo de verano; la propuesta de calendario de temáticas a publicar en el periodo de otoño; y la propuesta de campaña publicitaria del Informe del Observatorio Policy Brief.ITESO, A.C

Propuesta para la Reestructuración Funcional de la Figura del Coordinador de Virtualización en la UNED

El sistema organizativo académico de la Universidad Nacional de Educación a Distancia (UNED) está integrado por docentes en la Sede Central y profesores tutores en los Centros Asociados repartidos por el territorio español. A partir del nuevo panorama educativo en la enseñanza universitaria europea (Espacio Europeo de Enseñanza Superior, -EEES), la UNED se fue adaptando y situándose en un escenario moderno e innovador, iniciándose la mejora y homogeneización de los servicios que reciben los estudiantes mediante los cursos virtuales. En este contexto, se precisó la formación a profesores tutores y a estudiantes en la utilización de los cursos virtuales de la universidad, surgiendo así el rol del Coordinador de Virtualización (CV). En la actualidad hay 62 coordinadores (uno por cada centro asociado). Tras la implantación de las nuevas titulaciones dentro del marco del EEES y, una vez consolidada esta figura en la institución, se ha hecho necesario ofrecer una nueva organización en las funciones y tareas que los CV han de ejercer. Este trabajo describe la nueva propuesta organizativa diseñada para su aplicación a partir del próximo curso 2014-2015, y para cuya elaboración se han seguido los siguientes pasos: identificación del tipo de tareas a desarrollar (apoyo tecnológico a estudiantes y asesoramiento a profesores tutores), establecimiento de los contextos de trabajo (presencial y virtual), y clasificación por categorías para permitir una asignación de actividades básicas a todos los CV y de actividades más especializadas entre subgrupos de CV. Palabras llave: Aprendizaje semipresencial; Formación de profesorado; Competencias tecnológicas; Habilidades digitales. Virtualization Coordinator: Trainer of Tutor-Professors and Support for Students in the UNED Associate CenterAbstract The academic organizational structure of the Universidad Nacional de Educación a Distancia (UNED) is composed of professors at Central Headquarters and tutor-professors at the Associate Centers spread across the Spanish territory. From the new educational landscape in European university education (European Higher Education Area - EHEA), UNED was adapting and placing itself in a modern and innovative stage, beginning with the improvement and standardization of services provided to students through the online courses. In this context, training for both tutor-professors and students in the use of online courses was required, and that´s how the role of Virtualization Coordinator (VC) emerged. At present time, there are 66 VCs (one for each Associate Center). After implementation of the new qualifications within the framework of the EHEA and once established this role in the institution, it is necessary to provide a new organization in the functions and tasks that have to exercise VC. This paper describes a new organizational proposal designed for use from next year 2014-2015, and to whose development we have followed the following steps: identification of the type of tasks to be performed (technical support to students and advice to tutor-professors), establishment of working contexts (presential and virtual), and categorization to allow distribution of basic activities among all the VC, and more specialized activities among subgroups of VC.Keywords: Blended learning; Teachers training; Technological competences; Digital skills

Lack of associations of microRNAs with severe NAFLD in people living with HIV: discovery case-control study

Background & objectiveNonalcoholic fatty liver disease (NAFLD) is highly prevalent in people living with HIV (PLWH) and the expression of some microRNAs could be useful as biomarkers for the diagnosis of NAFLD. The aim of this study was to identify patterns of differential expression of microRNAs in PLWH and assess their diagnostic value for NALFD.MethodsA discovery case-control study with PLWH was carried out. The expression of miRNAs was determined using HTG EdgeSeq technology. Cases were defined as patients with severe NAFLD and controls as patients without NAFLD, characterized using the controlled attenuation parameter (CAP). Cases and controls were matched 1:1 for age, sex, BMI, CD4+ lymphocyte count, active HCV infection, and ART regimen.ResultsSerum 2,083 simultaneous microRNA transcripts were analyzed using HTG technology and compared between cases and controls. Forty-five patients, 23 cases, and 22 controls were included in the study. In the analysis of the expression pattern of the 2,083 microRNAs, no differential expression patterns were found between both groups of patients included in the study.ConclusionAnalysis of the microRNA transcriptome profile of nonobese PLWH with severe NAFLD did not appear to differ from that of patients without NAFLD. Thus, microRNA might not serve as a proper biomarker for predicting severe NALFD in this population

Home enteral nutrition in Spain: NADYA registry 2010

Objetivos: Describir los resultados del registro de nutrición enteral domiciliaria (NED) del grupo NADYASENPE del año 2010. Material y métodos: Se recopilaron los datos introducidos en el registro desde el 1 de enero al 31 de diciembre de 2010. Resultados: Se registraron 6.591 pacientes (51% varones) con 6.688 episodios de NED, procedentes de 32 hospitales. La edad media en los menores de 14 años (4%) fue de 1 ± 2 años (m ± DS) y de 69,9 ± 17,8 en los mayores de 14 años. El 76% de los pacientes recibieron la NED por un tiempo superior a 2 años. La patología más prevalente fue la neurológica 42%, seguida de la neoplasia 28% (en su mayoría cáncer de cabeza y cuello 18%). La información referente a la vía de acceso sólo se recogió en 626 casos (9,4%), el 51% de los pacientes utilizaron sonda nasogástrica, 27% gastrostomías, 10% vía oral y 3% yeyunostomías. Sólo 251 episodios finalizaron a lo largo del año, siendo el motivo más frecuente el fallecimiento del paciente en el 57% de los casos y el paso a la alimentación oral en el 14%. El 29% de los pacientes presentaban una actividad limitada y el 39% estaba confinado en cama/ sillón. El 68% de los adultos requerían ayuda total o parcial. El suministro del producto se realizó desde el hospital o la farmacia de referencia en el 63% y 34%, respectivamente. El suministro del material fungible se realizó desde el hospital o atención primaria en el 83% y 16%, respectivamente. Conclusiones: Los resultados obtenidos en el registro de NED del año 2010 muestran características muy similares a las recogidas en los años previos en cuanto al número y características de los pacientes registrados. Seguimos encontrando problemas en la recogida de datos relativos a la vía de acceso y finalización de los episodiosObjective: To describe the results of the home enteral nutrition (HEN) registry of the NADYA-SENPE group in 2010. Material and methods: We retrieved the data of the patients recorded from January 1st to December 31st 2010. Results: We registered 6,591 patients (51% males) with 6,688 episodes of HEN, from 32 hospitals. Mean age in those younger than 14 yr (4%) was 1 ± 2 yrs (m ± SD) and 69,9 ± 17,8 yrs in those older than 14 yr. The length of HEN was longer than 2 yrs in 76% of the patients. The most frequent underlying disease was neurological disorders 42%, followed by cancer 28% (mostly head and neck cancer 18%). We had information related to the enteral access route in only 626 cases (9,4%), 51% of them used nasogastric tubes, 27% gastrostomies, 10% oral route and 3% jejunostomies. Only 251 episodes were closed during the year, mostly due to patient death 57% and progress to oral diet 14%. The activity level was limited in 29% of the patients and 39% of them were bed- or chairridden. Total or partial help was needed by 68% of the patients. The hospitals and the private pharmacies delivered the enteral formula in 63% and 34% of the cases, respectively. The hospitals and the primary care centres delivered the disposables in 83% and16% of the cases, respectively. Conclusions: The results of the 2010 HEN registry are similar to those published in previous years regarding the number and characteristics of the patients. We continue finding problems in the entrance of data referred to the enteral access route and the closing of the episode